Publications, peer reviewed:
  1. Mikiko Oka, Sho Nakajima, Emiko Suzuki, Shinya Yamamoto, Kanae Ando. Glucose uptake in pigment glia suppresses tau-induced inflammation and photoreceptor degeneration in Drosophila. Disease Models and Mechanisms, dmm.052057.
  2. Homma D, Limlingan SJM, Saito T, Ando K. SARS-CoV-2-derived protein Orf9b enhances MARK2 activity via interaction with the autoinhibitory KA1 domain. FEBS Lett. 2024 Oct;598(19):2385-2393. doi: 10.1002/1873-3468.14975. Epub 2024 Jul 5. PMID: 38969617
    .
  3. Goodman LD, Ralhan I, Li X, Lu S, Moulton MJ, Park YJ, Zhao P, Kanca O, Ghaderpour Taleghani ZS, Jacquemyn J, Shulman JM, Ando K, Sun K, Ioannou MS, Bellen HJ. Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress. Nat Neurosci. 2024 Oct;27(10):1918-1933. doi: 10.1038/s41593-024-01740-1. Epub 2024 Aug 26. PMID: 39187706; PMCID: PMC11809452.
  4. Honda K, Takahashi H, Hata S, Abe R, Saito T, Saido TC, Taru H, Sobu Y, Ando K, Yamamoto T, Suzuki T. Suppression of the amyloidogenic metabolism of APP and the accumulation of Aβ by alcadein α in the brain during aging. Sci Rep. 2024 Aug 9;14(1):18471. doi: 10.1038/s41598-024-69400-9. PMID: 39122814; PMCID: PMC11316129.
  5. Shinno Kanako, Miura Yuri, Iijima Koichi M., Suzuki Emiko, Ando Kanae (2024) Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β eLife 13:RP95576 https://doi.org/10.7554/eLife.95576.1

  6. Crossley CA, Omoluabi T, Torraville SE, Duraid S, Maziar A, Hasan Z, Rajani V, Ando K, Hell JW, Yuan Q. Hippocampal hyperphosphorylated tau-induced deficiency is rescued by L-type calcium channel blockade. Brain Commun. 2024 Mar 20;6(2):fcae096. doi: 10.1093/braincomms/fcae096. PMID: 38562310; PMCID: PMC10984573.
  7. Sultanakhmetov G, Kato I, Asada A, Saito T, Ando K. Microtubule-affinity regulating kinase family members distinctively affect tau phosphorylation and promote its toxicity in a Drosophila model. Genes Cells. 2024 Apr;29(4):337-346. doi: 10.1111/gtc.13101. Epub 2024 Feb 8. PMID: 38329182; PMCID: PMC11447834

  8. Sultanakhmetov G, Limlingan SJM, Fukuchi A, Tsuda K, Suzuki H, Kato I, Saito T, Weitemier AZ, Ando K. Mark4 ablation attenuates pathological phenotypes in a mouse model of tauopathy. Brain Commun. 2024 Apr 17;6(3):fcae136. doi: 10.1093/braincomms/fcae136. PMID: 38712317; PMCID: PMC11073748.

  9. Maruko A, Iijima KM, Ando K. Dissecting the daily feeding pattern: Peripheral CLOCK/CYCLE generate the feeding/fasting episodes and neuronal molecular clocks synchronize them. iScience. 2023 Oct 6;26(11):108164. doi: 10.1016/j.isci.2023.108164. PMID: 37915609; PMCID: PMC10616324.
  10. Oba T, Homma D, Limlingan SJM, Fukuchi A, Asada A, Saito T, Ando K. A cell-penetrating peptide derived from SARS-CoV-2 protein Orf9b allosterically inhibits MARK4 activity and mitigates tau toxicity. Neurobiol Dis. 2023 Nov;188:106334. doi: 10.1016/j.nbd.2023.106334. Epub 2023 Oct 24. PMID: 37884211.
  11. Nozawa N, Noguchi M, Shinno K, Saito T, Asada A, Ishii T, Takahashi K, Ishizuka M, Ando K*. 5-Aminolevulinic acid bypasses mitochondrial complex I deficiency and corrects physiological dysfunctions in Drosophila. Hum Mol Genet. 2023 Jun 26:ddad092. doi: 10.1093/hmg/ddad092. Epub ahead of print. PMID: 37364055.
  12. Nozawa N, Noguchi M, Shinno K, Tajima M, Aizawa S, Saito T, Asada A, Ishii T, Ishizuka M, Iijima KM, Ando K*. 5-Aminolevulinic acid and sodium ferrous citrate ameliorate muscle aging and extend healthspan in Drosophila. FEBS Open Bio. 2021 Dec 1. doi: 10.1002/2211-5463.13338. PMID: 34854258.
  13. Saito T, Chiku T, Oka M, Wada-Kakuda S, Nobuhara M, Oba T, Shinno K, Abe S, Asada A, Sumioka A, Takashima A, Miyasaka T, Ando K*. Disulfide bond formation in microtubule-associated tau protein promotes tau accumulation and toxicity in vivo. Hum Mol Genet. 2021 Oct 13;30(21):1955-1967. doi: 10.1093/hmg/ddab162. PMID: 34137825; PMCID: PMC8522637.
  14. Oka M, Suzuki E, Asada A, Saito T, Iijima KM, Ando K*. Increasing neuronal glucose uptake attenuates brain aging and promotes life span underdietary restriction in Drosophila. iScience. 2021 Jan 5;24(1):101979. doi: 10.1016/j.isci.2020.101979. PMID: 33490892; PMCID: PMC7806808.
  15. Toshiya Oba, Taro Saito, Akiko Asada, Sawako Shimizu, Koichi M Iijima, Kanae Ando* Microtubule Affinity Regulating Kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration. J Biol Chem. 2020 Dec 11;295(50):17138-17147 .
  16. Miyuki Takahashi 1 2 , Arika Sugiyama 1 , Ran Wei 1 , Shizuka Kobayashi 3 , Kimiko Fukuda 4 , Hironori Nishino 1 , Roka Takahashi 1 , Koji Tsutsumi 1 5 , Ichiro Kita 6 , Kanae Ando 1 , Toshiya Manabe 3 , Hiroyuki Kamiguchi 7 , Mineko Tomomura 8 , Shin-Ichi Hisanaga 9Hyperactive and impulsive behaviors of LMTK1 knockout mice . Sci Rep . 2020 Sep 22;10(1):15461. doi: 10.1038/s41598-020-72304-z.
  17. Ran Wei, Arika Sugiyama, Yuta Sato, Motohiro Nozumi, Hironori Nishino, Miyuki Takahashi, Taro Saito, Kanae Ando, Mitsunori Fukuda, Mineko Tomomura, Michihiko Igarashi and Shin-ichi Hisanaga. Isoform-dependent subcellular localization of LMTK1A and LMTK1B, and their roles in axon outgrowth and spine formation. Journal of Biochemistry,  

  18. Nishino H, Saito T, Wei R, Takano T, Tsutsumi K, Taniguchi M, Ando K,Tomomura M, Fukuda M, Hisanaga SI.The LMTK1-TBC1D9B-Rab11A Cascade Regulates Dendritic Spine Formation via Endosome Trafficking. J Neurosci. 2019 Nov 27;39(48):9491-9502.
  19. Saito T, Oba T, Shimizu S, Asada A, Iijima KM, Ando K*. Cdk5 increases MARK4 activity and augments pathological tau accumulation and toxicity through tau phosphorylation at Ser262. Hum Mol Genet. 2019 Jun 7. pii: ddz120. doi: 10.1093/hmg/ddz120. [Epub ahead of print]  
  20. Sharma G, Huo A, Kimura T, Shiozawa S, Kobayashi R, Sahara N, Ishibashi M, Ishigaki S, Saito T, Ando K, Murayama S, Hasegawa M, Sobue G, Okano H, Hisanaga SI. Tau isoform expression and phosphorylation in marmoset brains. J Biol Chem. 2019 Jun 5. pii: jbc.RA119.008415. doi: 10.1074/jbc.RA119.008415. [Epub ahead of print]
  21. Takahashi M, Kobayashi Y, Ando K, Saito Y, Hisanaga SI. Cyclin-dependent kinase 5 promotes proteasomal degradation of the 5-HT1A receptor via phosphorylation.Biochem Biophys Res Commun. 2019 Mar 12;510(3):370-375. doi: 10.1016/j.bbrc.2019.01.093. Epub 2019 Jan 31.PMID: 30712943

  22. Chiku T., Hayashishita M., Saito T., Oka M., Shinno K., Ohtake Y., Shimizu S., Asada A., Hisanaga SI., Iijima KM, Ando, K*. S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy. Neurobiology of Aging, 3(71):255-264, 2018
  23. Sekiya M, Wang M, Fujisaki N, Sakakibara Y, Quan X, Ehrlich ME, De Jager PL, Bennett DA, Schadt EE, Gandy S, Ando K, Zhang B, Iijima KM. Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models. Genome Med. 2018 Mar 29;10(1):26. doi: 10.1186/s13073-018-0530-9.
  24. Tuerde D, Kimura T1, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, Ando K, and Hisanaga SI. Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development. J Biol Chem. 2018 Feb 2;293(5):1781-1793. doi: 10.1074/jbc.M117.798918. Epub 2017 Dec 1.

  25. Sekiya, M., Maruko-Otake, A., Hearn, S., Sakakibara, Y., Fujisaki, N., Suzuki, E., Ando, K., Iijima, K. M. EDEM Function in ERAD Protects against Chronic ER Proteinopathy and Age-Related Physiological Decline in Drosophila. Dev Cell. 2017 Jun 19;41(6):652-664.e5. doi: 10.1016/j.devcel.2017.05.019.

  26. Oka,M., Naoki Fujisaki, N., Maruko-Otake, A., Ohtake, Yl., Shimizu, S., Saito, T., Hisanaga,S., Iijima,KM., and Ando, K.* (2017) Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy. Journal of Biochemistry, 2017 Nov 1;162(5):335-342

  27. Kimura, T., Hosokawa, T., Taoka, T., Tsutsumi, T., Ando, K., Ishiguro, K., Hosokawa, M., Hasegawa, M. and  Hisanaga, S. (2016) Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants. Scientific Reports, ep 19;6:33479. doi: 10.1038/srep33479.

  28. Sharma, G., Tsutsumi, T., Saito, T., Asada, A., Ando, K., Tomomura, M., and Hisanaga, S. (2016) The kinase activity of endosomal kinase LMTK1A regulates its cellular localization and interactions with cytoskeletons. Genes to Cells, 2016 Oct;21(10):1080-1094. doi: 10.1111/gtc.12404.

  29. Ando, K*, Oka, M., Ohtake, Y., Hayashishita, M., Shimizu, S., Hisanaga, S., and Iijima, K.M.* (2016) Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated. Biochem Biophys Res Commun, Volume 478, Issue 2, Pages 929–934

  30. Ando, K.*, Maruko-Otake, A., Ohtake, Y., Hayashishita, M., Sekiya, M., and Iijima, K. M. (2016) Stabilization of microtubule-unbound tau via tau phosphorylation at Ser262/356 by Par-1/MARK contributes to augmentation of AD-related phosphorylation and Aβ42-induced tau toxicity. PLoS Genetics, (12(3): e1005917. doi:10.1371/journal. pgen.1005917)
Invited review:
  1. Samimi N., Asada A. and Ando K* Tau abnormalities and autophagic defects in neurodegenerative disorders; a feed-forward cycle (2019) Galen Medical Journal

Book chapters:
  1. Oka, M., Iijima, K.M. and Ando, K.* (2017) Loss of synaptic mitochondria and dementia.   Zikkennigaku, Yodosha (Japanese) Vol35, No12, p182-185, Yodosha .

  2. Ando, K.*, Hearn, A., Suzuki, E., Maruko-Otake, A., Sekiya, M., and Iijima, K.M. (2015) Electron microscopy of the brains of Drosophila Models of Alzheimer’s disease.    Neuromethods, DOI 10.1007/7657_2015_75, Springer